Leading the way for those left behind in pain


At Tremeau, we focus on patient populations whose pain management needs are not well-satisfied by the current standard of care. Our unique approach to acute and chronic pain in select conditions is rooted in the mechanism of action, documented efficacy in painful inflammatory conditions, and clinically differentiated profile of COX-2 selective NSAIDs.

Tremeau believes that the multiple, often industry-independent, scientific evaluations of the past 15+ years strongly suggest a re-examination of the potential utility of rofecoxib and etoricoxib. This is especially true with indications in which a COX-2 selective NSAID may provide therapeutic advantages over other standards of care, such as opioids.

TRM chartTRM chart

*The active ingredient in TRM-201 is rofecoxib, which was previously marketed as VIOXX®.
VIOXX is a registered trademark of Tremeau Pharmaceuticals, Inc.

Access information about the hemophilic arthropathy Phase III trial for TRM-201 and how to enroll.

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Focusing on migraine

Migraine is estimated to affect approximately 12% of the US population. It is the second most disabling condition worldwide and affects many aspects of everyday life.

NSAIDs are often used alone or in combination with other therapies for patients suffering from migraines. However, some people cannot or prefer not to take NSAIDs because of their inhibitory effect on platelet aggregation or their gastrointestinal adverse effects. Tremeau plans to focus on patient suffering from migraine whose needs are not satisfied by traditional NSAIDs.

woman sitting
Father and Kids

Focusing on hemophilic arthropathy

Hemophilic arthropathy (HA) is a painful and debilitating joint disease that affects people with inheritable bleeding disorders. It is caused by recurrent intra-articular bleeding. HA is one of the most common complications encountered by patients with bleeding disorders, and is the largest cause of morbidity in patients with hemophilia. There are currently no FDA-approved medications indicated to treat this type of joint pain, and opioids are the most frequently used prescription treatment.

Focusing on dysmenorrhea

Dysmenorrhea is pain related to menstruation. In up to 15% of women, this pain can be severe enough to limit their ability to participate in school, work, and other daily activities.

NSAIDs are frequently used alone or in combination with other therapies to treat dysmenorrhea. However, traditional NSAIDs are not recommended for everyone because of their inhibitory effect on platelet aggregation or their gastrointestinal adverse effects.

Among patients suffering from dysmenorrhea, 5-20% also suffer from menstrual migraines. These can be among the hardest attacks to prevent and treat.

Mother and Daughter

Expanded Access Policy

At Tremeau, we know there are patients and families in need of better non-opioid pain therapies. Because of this need, we are working to bring our investigational therapies to market as soon as possible for eligible patients.

Before we can make our investigational therapies available, we must first conduct clinical trials and obtain approval from the FDA to market those therapies.

Patients who are interested in participating in a Tremeau-sponsored clinical trial should search www.clinicaltrials.gov for planned, active, recruiting, and ongoing trials. When considering any clinical trial, patients should talk with their doctor about potential benefits, risks, and feasibility.

In some circumstances, patients who cannot participate in clinical trials seek access to investigational medicines outside of a clinical trial setting. This is often referred to as “early access,” “expanded access,” or “compassionate use.”

At this time, we do not offer expanded access to TRM-201 or our other investigational therapies. We are focused on developing these therapies so that we can make them available to eligible patients as soon as possible.

Any changes to the policy will be posted to this website. For additional information patients, families or physicians may email us at info@tremeau.com.